What is PI?
PI stands for primary humoral immunodeficiency disease. There are more than 400 different kinds of PI.1 When you have PI, part of your immune system, which is what protects you from infections and fights off diseases, is missing or doesn't function properly. As a result, your body can't protect you from germs as well as it should, so you are more likely to develop infections and be sick more often. Learn more about PI.
What causes PI?
PI is a genetic disorder in which the immune system is compromised. When the immune system is not working properly, the body's defense system has a hard time fighting off germs, resulting in frequent, recurring infections and a person getting sick more often than he/she should.
What are symptoms of PI?
The signs and symptoms of PI vary from person to person. The most common symptoms include1,2:
- Chronic, recurring infections that are more severe, longer lasting, and more difficult to cure, such as sinus infections, when compared to people with healthy immune systems
- Frequently getting sick with infections, such as a common cold, that a healthy immune system would normally be able to fight off
- Autoimmune problems, such as autoimmune lung or skin disease, which happen when the immune system attacks the body's own organs. Other issues include anemia, celiac disease, arthritis, lupus, and thyroid disorders
Can I catch PI? Is PI contagious?
PI is not contagious; you can't catch it from someone else. PI is usually inherited, which means it is carried through the genes of your parents. If you have the disease, you might pass it along to your children, but you won't give it to anyone else.1
What medications are used to treat PI?
Most doctors recommend immune globulin replacement therapy as it treats PI directly. Over-the-counter drugs such as aspirin, decongestants, and/or expectorants are used to treat symptoms. Antibiotics are also used to treat infections and deal with a wide range of germs that have a greater impact on people with PI.2
What is immune globulin (IG)?
IG stands for immune globulin. Immune globulin, or IG, is a medicine made from healthy proteins taken from human plasma and contains purified antibodies. Plasma is the liquid part of the blood that contains antibodies needed to keep the body healthy.
Immune globulin is given to people with PI to replace missing proteins to help the immune system protect against germs and other threats. It is sometimes referred to as IG replacement therapy.
What's the difference between subcutaneous IG therapy and intravenous IG therapy?
Subcutaneous immune globulin (SCIG) is administered under the skin while intravenous immune globulin (IVIG) therapy is administered through a vein. Different IG products have different concentrations. This means they may require more or less volume to be infused. XEMBIFY is a subcutaneous immune globulin (SCIG) replacement treatment used to treat PI in patients 2 years of age and older.