Patients Infusing video
XEMBIFY Self-Administration Video
Experience the freedom and flexibility of administering your own infusions with a routine that's convenient for you. Watch this instructional video designed to help you learn about XEMBIFY self-infusion so you can feel comfortable and prepared for therapy.
You can also follow the step-by-step instructions on how to infuse below.
Patients Infusing Before
Before the infusion
Before you start your infusion, take the vial of XEMBIFY out of the fridge and allow the vial to reach room temperature. This may take 60 minutes or longer. DO NOT apply heat to the vial(s) or place in the microwave, instead, let the vial(s) warm to room temperature naturally.
patients infusing 1
1. Disinfect surface to be used for your infusion. Allow the vial(s) of XEMBIFY to reach room temperature. Set up all of the supplies you will need. Wash and dry your hands thoroughly.
patients infusing 1b
2. Check the vial of XEMBIFY. Confirm the name and expiration date. If the product is past the expiration date, if the liquid is cloudy or has particles, or if the vial shows any sign of tampering, do not use that vial. Contact your specialty pharmacy for guidance in that case.
3. Remove the tamper-resistant seal and protective cap from the vial of XEMBIFY. Clean the rubber stopper with a disinfecting wipe and allow to air dry.
4. Draw XEMBIFY into the syringe using either a needle or a transfer device. If you are using a needle, refer to Step 5. If using a transfer device, refer to Step 6.
5. Attach the needle to the syringe tip and remove the cap. Pull the syringe plunger back to the level of XEMBIFY you want to withdraw. Place the vial on a flat surface, insert the needle and inject air. Turn the vial and syringe upside down. Make sure the needle is placed below the fluid level and withdraw XEMBIFY.
6. Uncap the transfer device and attach it to the syringe. Place the vial on a flat surface and insert the device into the top of the vial. Turn the vial and syringe upside down and withdraw the desired amount of XEMBIFY. Then, remove the syringe and transfer device.
7. Follow the pump manufacturer's instructions to attach the infusion tubing and needle set to the syringe. Be sure to prime the administration tubing by filling it with XEMBIFY. Make sure the needle remains dry while priming.
8. XEMBIFY is infused in the abdomen, thigh, upper arm, sides, back or hip. Select one or more infusion sites as directed by your healthcare provider. Be sure to choose sites that are different from your last infusion.
9. Prepare the infusion site(s) by cleaning with an alcohol wipe. The sites should be clean, dry, at least 2 inches apart, and 2 inches away from the belly button. Do not use more than 6 infusion sites at the same time.
10. Grasp the skin between 2 fingers and insert the needle into the subcutaneous tissue, which is the innermost layer of your skin. Secure needle with adhesive dressing. Repeat for other sites as needed.
11. After securing the needle, make sure a blood vessel has not been entered. If you see blood when pulling back on the plunger, remove and discard the needle and tubing. Repeat steps 8-10 using a new needle, administration tubing, and a new infusion site.
12. Follow the pump manufacturer's instructions to load the syringe and start the infusion. The infusion is complete when the syringe is empty.
Patients Infusion After
After the infusion
- Wash your hands again.
- Follow manufacturer's instructions to turn off the pump.
- Undo and discard any dressing or tape.
- Gently remove inserted needle(s).
- Discard used needles and tubing in a sharps container.
- Store your supplies in a safe place.
- Follow manufacturer's instructions to care for the infusion pump.
Patient Infusing Record
Record the infusion
Record each infusion in your Infusion Log Book, by removing the peel-off labels with the product lot number(s) and expiration date(s) from the XEMBIFY vial(s) and sticking these into your Infusion Log Book.
Learn more about the Infusion Log Book and other resources so you can make every infusion of XEMBIFY as convenient and comfortable as possible.
Patients Infusing Be sure
Be sure to record each infusion of XEMBIFY and remember to share your log book with your healthcare professional at every visit.
Patients Infusing Please
Patient Infusing callout
Subcutaneous IG Therapy FAQs
View our FAQs about infusing XEMBIFY for more information.
What Is PI?
Understand more about the symptoms of PI and how it's diagnosed.
Learn more about XEMBIFY educational resources and PI patient organizations.
What is XEMBIFY®?
XEMBIFY® (immune globulin subcutaneous human–klhw) is a 20% immune globulin used in the treatment of primary humoral immunodeficiency disease (PIDD) in patients 2 years of age and older. XEMBIFY is for subcutaneous administration only.
IMPORTANT SAFETY INFORMATION
- Thrombosis (formation of blood clots within blood vessels) may occur with immune globulin products, including XEMBIFY. Before you take XEMBIFY, talk to your doctor if you:
- Are older
- Are sedentary (need to lie down or sit down) for long periods of time
- Are taking estrogen-containing medicines (birth control pills, hormone replacement therapy)
- Have a permanent intravenous (IV) catheter
- Have hyperviscosity of the blood (diseases such as multiple myeloma or other causes of elevated proteins in the blood)
- Have cardiovascular (heart) problems or previous history of stroke
- Thrombosis may occur even if you don't have any risk factors
- If you are at risk of thrombosis, your doctor may prescribe XEMBIFY at the minimum dose and infusion rate. Make sure you drink plenty of fluid before taking XEMBIFY. Make sure your doctor is checking you regularly for signs and symptoms of thrombosis and is checking your blood viscosity if you are at risk of hyperviscosity
Who should not use XEMBIFY?
- XEMBIFY should not be used if you have had a severe allergic reaction to human immune globulin, or if you have been told by a doctor that you are IgA deficient and have developed antibodies to IgA and hypersensitivity after exposure to a previous plasma product
What are possible serious side effects of XEMBIFY?
- Hypersensitivity. Severe allergic reactions may occur with immune globulin products, including XEMBIFY. If you have a severe allergic reaction, stop the infusion immediately and get medical attention. XEMBIFY contains IgA. If you have known antibodies to IgA, you may have a greater risk of developing potentially severe allergic reactions
- Aseptic meningitis syndrome (AMS). Aseptic meningitis is a non-infectious inflammation of the membranes that cover the brain. It causes a severe headache syndrome, which may occur with human immune globulin treatment, including XEMBIFY. If you are showing signs and symptoms of AMS, your doctor may conduct a thorough neurological evaluation including spinal tap (sampling fluid which surrounds the spinal cord) to rule out other causes of meningitis. Stopping human immune globulin treatment has resulted in the end of signs and symptoms within several days. Treatment may include analgesics (pain medicines) and/or a special procedure known as a "blood patch" to stop headache
- Kidney problems or failure. Kidney problems or failure may occur with use of human immune globulin products, especially those containing sucrose (sugar). XEMBIFY does not contain sucrose. If you have kidney disease or diabetes with kidney involvement, your doctor should perform a blood test to assess your hydration level and kidney function before beginning immune globulin treatment and at appropriate intervals thereafter. If your doctor determines that kidney function is worsening, they may discontinue treatment
- Hemolysis. Your doctor should monitor you for symptoms of hemolysis (destruction of red blood cells causing anemia, or low red blood cell count). If your doctor suspects hemolysis, they should perform additional tests to confirm
- Transfusion-related acute lung injury (TRALI). TRALI is a rare but serious syndrome characterized by sudden acute respiratory distress following transfusion. If your doctor suspects TRALI, they will monitor you for any other lung issues. TRALI may be managed with oxygen therapy
- Transmissible infectious agents. Because XEMBIFY is made from human blood, it may carry a risk of transmitting infectious agents such as viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. No cases of transmission of viral diseases or CJD have been associated with the use of XEMBIFY
- Interference with lab tests. Because XEMBIFY contains a variety of antibodies, blood tests to determine antibody levels may be falsely elevated. Be sure to tell your doctor or lab technician that you are using XEMBIFY
What are other possible side effects of XEMBIFY?
- In clinical studies of XEMBIFY, some patients experienced local side effects (at the injection site) including pain, redness, puffiness, bruising, nodules, itching, firmness, scabbing and swelling at the site on the skin where the injection occurred. Some patients experienced non-injection-site side effects including cough and diarrhea.
- Use of XEMBIFY may interfere with the immune response to virus vaccines, such as vaccines for measles, mumps, rubella and varicella. Tell your doctor you are taking XEMBIFY before getting vaccinations
Please see full Prescribing Information for XEMBIFY.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.